How does Onda Coolwaves work?
Onda utilizes high-frequency electromagnetic currents (Coolwaves™) to provide localized adiposity, cellulite treatment and skin laxity treatments all in one device, all over the body* (excluding the face, neck and terminal part of the limbs).
Differently from existing technologies, Onda focalizes its action on the subdermal fat by means of selective electromagnetic current, Coolwaves™ delivered to the subdermal layers from two specially designed handpieces able to drive all the energy right to the selected target
The synergy in between the two handpieces allows for:
Regression of the cellulite;
Reduction of localised fat deposits;
Toned, elastic skin with a reduction in flabbiness;
Harmonious remodelling of the body contours.
What is Coolwaves?
Coolwaves™: the Foremost in Microwave Technology
Microwave technology is very popular in the modern society and it is not a new comer in medical applications either. It has been widely used in many branches of medicine up to now including Oncology. It has been proven to be highly safe for use on humans too. The selective microwave frequency Onda works at, is 2.45GHz. Such a frequency it has been discovery to make skin tissue to be almost “transparent” to the passage of the energy so to make it free to work almost totally over the subdermal fat layer specifically. This makes the superficial layers of the dermis to be preserved from unwanted heating and to stay cool. For this reason the microvawes Onda works with, are now denominated Coolwaves™.
What does Coolwaves do to adipocytes (fat cells)?
Coolwaves™ targeted action on adipose tissue, produces the following effects:
Remodeling of the connective tissue matrix with consequent modification of the microenvironment that regulates the Adypocites metabolism. The homeostatic balance between the adipocytes and the connective interstitium that defines the vital conditions of the adipose tissue is therefore altered.
Adypocite metabolic changes by induced thermal stress. Adypocites are therefore stimulated to release a quantity of lipids much higher than their physiological capacity in the outer environment.
Action on the fat:
Coolwaves™ intense stimulation, put adipocytes under a strong stress condition so to induces metabolic changes. These modifications lead the adipocytes to release part of their lipid content outside, in the cellular interstitium, through a mechanism called “blebbing”: the droplets of fat reach the plasma membrane where they are surrounded by evaginations of the membrane which give the cell a bubble- like appearance. The bubbles once detached from the adipocyte, bring the lipid content to the outer interstitial connective tissue. This mechanism is so intense that it initiates a process of lysis of fat cells with adipocyte membrane rupture. The large amount of droplets of fat that are poured into the interstitial connective, stimulates the recall of the macrophages from the blood that have the task of “cleaning” the cellular interstitium from the excess of fatty acids, engulf the excess free fat. When the condition of normality is restored, the macrophages migrate into the lymphatic system
How Onda Compares To Other Devices Claiming To Achieve Fat Reduction Of More Than 24% With A Single Treatment
Onda Coolwaves fat reduction results are capable of reaching temperatures that greatly exceed the treatment effect that laser and bi-polar radio-frequency use to achieve greater than 24% fat-reduction from a single treatment.
Research has defined key temperature thresholds for effective non-surgical fat reduction1:
Maintaining a controlled temperature of 42-47 ̊C will cause the cell membranes of the targeted adipocytes lose their structural integrity and this loss of cellular structure leads to delayed cell death. 
Adipocyte viability is reduced by 60% after 3 minutes treatment at 45°C.1
At 50°C for just one minute the reduction in adipocyte viability rises to 80%, an additional 20% reduction compared to the longer 45°C treatment
Two minutes at 50°C improves the effect further and causes an 84% reduction in adipocyte viability1, an additional 24% reduction compared to the longer 45°C treatment
Research on body-contouring treatments shows fat reduction of 24.7% with one treatment at a temperature of ~45°C 1  and 24% with temperatures in the range of 42°C to 47°C .
Onda Coolwaves achieve temperatures of 50°C - 53°C in the subdermal fat layer while keeping the skin cool and comfortable (38°C-42°C). Based on this Onda delivers greater likelihood of effective fat reduction results, and offers additional benefits of cellulite reduction and skin-tightening.
Onda Can Reach Key Temperature Thresholds For Collagen Stimulation & Septal Tightening That Crolipolysis, RF & Laser Fat Reduction Can’t Match!
Onda Coolwaves can achieve key temperature thresholds that other fat reduction technologies are unable to reach. While collagen remodelling occurs at 42°C–46°C, and skin tightening and lifting effects occur in 40°C–50°C range, higher temperatures are required to effectively target cellulite and deliver longer term collagen changes.
Research suggests skin collagen formation and cell proliferation requires temperatures to exceed 50°C5, and for septal tightening, which is required for effective cellulite reduction, temperatures in the range of 55°C are required6. Lin et al also noted that compared with lower-temperature results, the SHG images at 52 ° C and 55 ° C indicate that collagen fibers tend to demonstrate a greater degree of curvature with increasing temperature. 
Subdermal temperature measurement of Onda Coolwaves treatments have found that a skin temperature of 38°C-39°C with the deep handpiece equates to 50°C - 53°C in the fat layer. Applying skin temperatures close to the patient’s pain threshold of ~43°C allows Onda Coolwaves treatments to deliver the heat thresholds required for septal tightening and longer-lasting cellulite reduction.
Onda Delivers Greater Treatment Effect With Superior Comfort Levels
Pain receptors for heat are mostly located in the top half a millimetre of the skin.  Radio-Frequency deposits 70% of its heating at this level, resulting in higher levels of pain. Onda only deposits 20% of its heat energy at this level of the skin.
The heat-pain threshold ‘is defined as the lowest heat stimulation intensity which is characterized as painful by a volunteer or patient’1 and is commonly observed in research to equate to a heat-pain threshold around 43°C.   Research on Radio-frequency fat reduction devices has found 45°C was the highest local steady-state temperature that could be established with a bi-polar Radio-frequency device without anaesthetic because of the cutaneous heat-pain constraint.1 Despite having the technical means to heat the fat to 50°C patients could not tolerate the treatment at this temperature for longer than 2 minutes due to extreme discomfort.
Onda Coolwaves in comparison can keep the skin at a comfortable temperature of 38°C-39°C with the deep handpiece, and/or 39°C-42°C with the shallow handpiece, while maintaining temperatures of 50°C - 53°C in subdermal layers.
Onda Treats More Body Area Than Other Non-Surgical Fat Reduction Devices
Onda treats more area in less time than other devices. Onda can treat an 675cm2 in 30 minutes, with single 15cm by 15cm areas in as little as 8 minutes. The next closest competitor is limited to treating 600cm2 in 30 minutes (300 cm2 per 15 minutes).
 Franco W, Kothare A, Ronan SJ, et al. Hyperthermic injury to adipocyte cells by selective heating of subcutaneous fat with a novel radiofrequency device: feasibility studies. Laser Surgical Med. 2010;42:361-370.
 Amy Taub, MD ASDS 2017 Poster Presentation.
 Decorato JW, Sierra R, Chen B. Clinical and Histological Evaluations of a 1060nm Laser Device for Non-Invasive Fat Reduction. Paper presented at: 2014 Annual American Society for Laser Medicine and Surgery Conference; April 2-6; Phoenix, AZ.
 Schilling, Laura & Saedi, Nazanin & Weiss, Robert. (2017). 1060 nm Diode Hyperthermic Laser Lipolysis:The Latest in Non-Invasive Body Contouring. Journal of drugs in dermatology : JDD. 16. 48-52.
 2019 Deka Onda Frequently Asked Questions Report - page 10: Intradermal thermal probe measurement data on file
 Kinney BM, Andriessen A, DiBernardo BE, Bloom J, Branson DF, Gentile RD, et al. Use of a controlled subdermal radio frequency thermistor for treating the aging neck: Consensus recommendations. J Cosmet Laser Ther 2017;19:444-50.
 Elman M,,Gauthier N, Belenky I. New vision in fractional radio-frequency technology with switching, vacuum and cooling. J Cosmet Laser Ther 2015;17:60-4.
 Lin, Sung-Jan & Hsiao, Chih-Yuan & Sun, Yen & Lo, Wen & Lin, W.-C & Jan, Gwo-Jen & Jee, Shiou-Hwa & Dong, Chen-Yuan. (2005). Monitoring the thermally induced structural transition of collagen by use of SHG microscopy. Optics letters. 30. 622-4. 10.1364/OL.30.000622.
 Tillman DB, Treede RD, Meyer RA, Campbell JN. Response of c fibre nociceptors in the anaesthetized monkey to heat stimuli: Estimates of receptor depth and threshold. J Physiol 1995;485(Pt 3):753 – 765.
 Plaghki L, Mouraux A. How do we selectively activate skin nociceptors with a high power infrared laser? physiology and biophysics of laser stimulation. Neurophysiol Clin 2003; 33(6):269 – 277.
 Yarnitsky D, Sprecher E, Zaslansky R, Hemli JA. Heat pain thresholds: Normative data and repeatability. Pain 1995; 60(3):329 – 332.
 Jrum E, Warncke T, Stubhaug A. Cold allodynia and hyperalgesia in neuropathic pain: The effect of n-methyl-d- aspartate (nmda) receptor antagonist ketamine—A double- blind, cross-over comparison with alfentanil and placebo. Pain 2003;101(3):229–235.
 Arendt-Nielsen L, Chen ACN. Lasers and other thermal stimulators for activation of skin nociceptors in humans. Neurophysiol Clin 2003;33(6):259 – 268.